Senior Manager CEREBRA Unit

HT - Human Technopole

Senior Manager CEREBRA Unit

HT - Human Technopole

Milan, Italy

Job description


Human Technopole (HT) is a new interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health. HT is composed of five Centres: Computational Biology, Structural Biology, Genomics, Neurogenomics and Health Data Science. The Centres work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally.

The Human Technopole Foundation is looking for a Senior Manager of the CEll REference BRain Atlas (CEREBRA) Scientific Support unit for the HT Centre for Neurogenomics.

The successful candidate, reporting to the Head of the Centre for Neurogenomics, will be responsible for developing, maintaining and constantly evolving a research support unit performing the systematic integration of both publicly available and in-house generated single cell resolved omics datasets (including spatial omics) of the human brain and brain organoids into a Reference Atlas. Through iterative cycles of update and improvement, this Atlas will constitute a key continuously evolving resource to enable the streamlined interpretation of experimental results interrogating developmental trajectories and disease phenotypes. Working in close cooperation with a vibrant community of computational biologists from the Neurogenomics Centre, the Image Analysis Facility and the Computational Biology Centre, they will also integrate manually curated endophenotypes, including single cell expression values, differentially expressed genes, and developmental trajectories, cell populations data (relative abundance, cell type-specific eQTL) and metadata (clinical phenotype, genetic background) for the creation and continuous adaptation of an easy-to-use interface to connect and explore Neurogenomics datasets.

Main tasks and responsibilities:

  • Generation and maintenance of a human brain and brain organoids Reference Atlas that integrates single cell multi-omic resolved datasets;
  • Continuous integration within the Reference Atlas of new datasets, generated both within the Neurogenomics Research Centre, the partner Centres (Genomics and Computational Biology Research Centres) and within the scientific community;
  • Analysis, curation and interpretation of the single cell resolution datasets;
  • Generation and maintenance of an easy to use user interface that enables to access and interactively explore the Reference Atlas;
  • Supervise the Unit staff and collaborate within and outside the Neurogenomics Centre to optimize the flow of information and the required standardisation;
  • Supporting grant applications, paper writing and project reporting.

Job requirements

  • At least 5 years of proven experience in computational biology with a clear focus on neurobiology;
  • Extensive experience in computational approaches applied to omics bulk and single-cell data for the dissection of the molecular mechanisms. underlying the development and disorders of the central nervous system, including in omics-based benchmarking of cutting-edge experimental systems, especially brain organoids;
  • Fluency in English – HT is an international research institute;
  • Excellent knowledge of Microsoft Office 365 and related managing tools;
  • Excellent written and verbal communication and interpersonal skills;
  • Excellent problem-solving, organizational, analytical and critical thinking skills;
  • Excellent negotiation and conflict resolution attitude;
  • Ability to manage competing priorities in a fast-paced environment;
  • Ability to manage internal and external confidential information with utmost discretion;
  • Close attention to details.

Application Instructions

Please apply online sending:

  • a full CV;
  • a motivation letter, including a description of the background relevant to this post;
  • name and contact details of at least 2 potential referees.

HT offers a highly collaborative, international culture. The working language at HT will be English. HT will foster top-quality, interdisciplinary research by promoting a vibrant environment consisting of independent research groups with access to outstanding graduate students, postdoctoral fellows, and core facilities.

Additional information

HT is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to a leading, internationally competitive, research organization and seeks to promote a collegial and open atmosphere. The compensation package granted will be internationally competitive and comprise a pension scheme, medical and other social benefits, and support for relocation and installation.

For specific enquires concerning the role only, please contact Prof. Giuseppe Testa, Head of the Center for Neurogenomics: (this email address should not be used to send applications).

Please apply sending a CV and motivation letter in English only through the dedicated area in the website.

Number of positions offered: 1
Contract offered: CCNL Chimico Farmaceutico, permanent - Quadro level

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EuroJobsites is a registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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